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GENERIC NAME: diazepam
BRAND NAME: Valium

DRUG CLASS: Diazepam is a member of the benzodiazepine family. Benzodiazepines are sedatives that cause dose-related depression of the central nervous system. They are useful in treating anxiety, insomnia, seizures, and muscle spasms.

PRESCRIPTION: yes

GENERIC AVAILABLE: yes

PREPARATIONS: Tablets (2mg, 5mg, 10mg).

STORAGE: Diazepam should be stored at room temperature in a tightly closed container.

PRESCRIBED FOR: Diazepam is used for the short-term relief of symptoms related to anxiety disorders. Diazepam is also used for the treatment of agitation, tremors, delirium, seizures, and hallucinations as a result of alcohol withdrawal. Diazepam is also used for relief of muscle spasms in certain neurological diseases. Diazepam is used to abort active seizures and can be combined with other drugs in treating severe recurrent seizures.

DOSING: Diazepam may be taken with or without food. Diazepam is metabolized by the liver and excreted mainly by the kidney. Dosages of diazepam may need to be lowered in patients with abnormal kidney function.

DRUG INTERACTIONS: Alcohol should be avoided by patients taking benzodiazepines. Diazepam can lead to addiction (dependency), especially at higher dosages over prolonged periods of time. Because of diazepam’s addicting potential, dosages should never be increased by the patient. In patients addicted to diazepam, abrupt discontinuation of the medicine can lead to symptoms of withdrawal (insomnia, headaches, nausea, vomiting, lightheadedness, sweating, anxiety, and fatigue). Seizures can occur in more severe cases of withdrawal. Consequently, patients on diazepam for extended periods of time should slowly taper the medication under a doctor’s supervision rather than abruptly stopping the medication. Tagamet can prolong the effects of diazepam and dosages may need to be decreased when these drugs are used together.

PREGNANCY: Benzodiazepines, such as diazepam, can cause fetal problems and should not be used in pregnancy.

NURSING MOTHERS: Benzodiazepines, such as diazepam, can cause fetal problems and should not be used in breast feeding mothers.

Valium is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
In acute alcohol withdrawal, Valium may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
As an adjunct prior to endoscopic procedures if apprehension, anxiety or acute stress reactions are present, and to diminish the patient’s
Valium is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma); spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia); athetosis; stiff-man syndrome; and tetanus.
Valium Injection is a useful adjunct in status epilepticus and severe recurrent convulsive seizures.
Valium is a useful premedication (the IM route is preferred) for relief of anxiety and tension in patients who are to undergo surgical procedures. Intravenously, prior to cardioversion for the relief of anxiety and tension and to diminish the patient’s recall of the procedure.

Dosage should be individualized for maximum beneficial effect. The usual recommended dose in adults ranges from 2 mg to 20 mg IM or IV, depending on the indication and its severity. In some conditions, eg, tetanus, larger doses may be required. (See dosage for specific indications.) In acute conditions the injection may be repeated within 1 hour although an interval of 3 to 4 hours is usually satisfactory. Lower doses (usually 2 mg to 5 mg) and slow increase in dosage should be used for elderly or debilitated patients and when other sedative drugs are administered (see WARNINGS and ADVERSE REACTIONS).
For dosage in pediatric patients above the age of 30 days, see the specific indications below. When intravenous use is indicated, facilities for respiratory assistance should be readily available.
Intramuscular: Valium Injection should be injected deeply into the muscle.
Intravenous Use: (See WARNINGS and PRECAUTIONS: Pediatric Use.) The solution should be injected slowly, taking at least 1 minute for each 5 mg (1 mL) given. Do not use small veins, such as those on the dorsum of the hand or wrist. Extreme care should be taken to avoid intraarterial administration or extravasation.
Do not mix or dilute Valium with other solutions or drugs in syringe or infusion flask. If it is not feasible to administer Valium directly IV, it may be injected slowly through the infusion tubing as close as possible to the vein insertion.